Built in 1880, Old Main was the first building constructed on Wartburg's Waverly campus. It is listed in the National Register of Historic Places.

Old Main once housed the entire college, providing classrooms, library space, eating facilities, and sleeping quarters for students and living space for the college president. Over the years, Old Main housed the music department, the business administration and economics department, and the religion department.

Old Main currently houses the education and social work departments. The Health and Wellness Center is located on the lower level.